Brain of London is the title The Quiz League of London awards to the winner of the annual individual competition. The competition is open to all quizzers regardless of their league affiliation or lack thereof.
The MIMIR format is used, having been imported from the Merseyside Quiz Leagues in 1992. In recent years, the competition has been dominated by Kevin Ashman who until 2008 had an 100% success rate in the contests he entered.
In 2006 a qualifying competition was introduced, resulting in a big increase in participation. The players who qualify take part in the preliminary event to decide the four finalists who will battle it out on finals night.
Matches take place in groups of four, drawn out of the hat. Each person has three questions addressed to them, in each of five rounds. You can take your time to answer but a wrong answer or a pass gives any of the other three an opportunity to score a bonus point. Who should get the first chance to answer for a bonus is determined by offering the question to whoever, at that stage, has made least attempts to gain bonus points.
The winner is awarded the R S Yule Trophy, named in memory of Robert Scott Yule 1906-1982.
| Year | Winner | Team |
| 2008 | Robert Willer | Atletico |
| 2007 | Kevin Ashman | Allsorts |
| 2006 | Kevin Ashman | Allsorts |
| 2005 | Kevin Ashman | Allsorts |
| 2004 | Kevin Ashman | Allsorts |
| 2003 | Kevin Ashman | Allsorts |
| 2002 | Mike Billson | Rising Sons |
| 2001 | Robert Willer | Atletico Manor |
| 2000 | Kevin Ashman | Allsorts |
| 1999 | Kevin Ashman | Allsorts |
| 1998 | Adrian Perry | Mannor Corinthians |
| 1997 | Kevin Ashman | Allsorts |
| 1996 | Kevin Ashman | Allsorts |
| 1995 | Kevin Ashman | Allsorts |
| 1994 | Tony Sherwood | The Beehive |
| 1993 | Tony Sherwood | The Beehive |
| 1992 | Donald Yule | Manor Athletic |
| Division 1 | Pts | Avg | W | D | L | |
| 1 | Allsorts | 4 | 50.00 | 1 | 0 | 0 |
| 2 | Old Itonians | 4 | 44.00 | 1 | 0 | 0 |
| 3 | Broken Hearts | 4 | 43.00 | 1 | 0 | 0 |
| 4 | Atletico | 4 | 42.00 | 1 | 0 | 0 |
| 5 | Barb | 0 | 38.00 | 0 | 0 | 1 |
| 6 | Pineapple | 0 | 38.00 | 0 | 0 | 1 |
| 7 | Gray Monks | 0 | 33.00 | 0 | 0 | 1 |
| 8 | Waterloo Sunset | 0 | 28.00 | 0 | 0 | 1 |
| 9 | Nomads | 0 | 0.00 | 0 | 0 | 0 |
| Division 2 | Pts | Avg | W | D | L | |
| 1 | Pericardium | 4 | 51.00 | 1 | 0 | 0 |
| 2 | Ovalytes | 4 | 47.00 | 1 | 0 | 0 |
| 3 | Rosslyn Park | 4 | 42.00 | 1 | 0 | 0 |
| 4 | Belly | 4 | 40.00 | 1 | 0 | 0 |
| 5 | Telstars | 0 | 33.00 | 0 | 0 | 1 |
| 6 | Mealy Bugs | 0 | 27.00 | 0 | 0 | 1 |
| 7 | Accrington Cylindricals | 0 | 16.00 | 0 | 0 | 1 |
| 8 | Wharfside | 0 | 16.00 | 0 | 0 | 1 |
| 9 | London Scottish | 0 | 0.00 | 0 | 0 | 0 |