In Division I Allsorts picked up where they left off last season, with a comfortable win over Priory Nomads. Newly promoted Broken Hearts got off to a good start back in Division I with a win away to Barbican. However the other promoted team, the renamed Belly, were overwhelmed by the Animals, failing to score in both the first and last rounds. In the clash between last season's joint runners-up, Atletico seemed to be easing to a win against Chester Army, but a disastrous round 7 left them grateful to hold on for a draw. David Lea of Animals was the week's top scorer with 25 points, which included the season's first full house.
Division II newcomers Aldersgate started with a narrow win over Uncosy, despite failing to trouble the scorers in the last round. In the battle of the rugby clubs, London Scottish had a clear win over Rosslyn Park, while Waterloo Sunset had a comfortable win against Accrington Cylindricals. In the week's other game, last season's two relegated teams met, with Bread & Roses coming out on top against Telstars. Top scorers in the Division were Peter Ediss of Uncosy and Bob Jones of Waterloo Sunset, both with 18 points.
Week 1 - 27 September 2005
League - Division 1 - Fixtures 2005-2006
| Team | P | W | D | L | F | A | +/- | Pts |
| Animals | 1 | 1 | 0 | 0 | 50 | 29 | 21 | 2 |
| Allsorts | 1 | 1 | 0 | 0 | 51 | 41 | 10 | 2 |
| Broken Hearts | 1 | 1 | 0 | 0 | 48 | 40 | 8 | 2 |
| Atletico | 1 | 0 | 1 | 0 | 44 | 44 | 0 | 1 |
| Chester Army | 1 | 0 | 1 | 0 | 44 | 44 | 0 | 1 |
| Barbican | 1 | 0 | 0 | 1 | 40 | 48 | -8 | 0 |
| Priory Nomads | 1 | 0 | 0 | 1 | 41 | 51 | -10 | 0 |
| Belly | 1 | 0 | 0 | 1 | 29 | 50 | -21 | 0 |
| Allsorts Kevin Ashman 22 Gavin Fuller 14 Ken Emond 11 | 51 - 41 | Priory Nomads Roger Bennett 14 Richard Jones 14 |
| Animals David Lea 25* Paul Steeples 10 | 50 - 29 | Belly Mick Lancaster 15 |
| Atletico Brian Wright 15 Robert Willer 14 Roger Barnes 10 | 44 - 44 | Chester Army Fred Filby 18 John Grant 13 |
| Barbican Donald Yule 19 Roger Robinson 10 | 40 - 48 | Broken Hearts Ian Bayley 22 Sean Carey 12 Jesse Honey 10 |
League - Division 2 - Fixtures 2005-2006
| Team | P | W | D | L | F | A | +/- | Pts |
| Waterloo Sunset | 1 | 1 | 0 | 0 | 45 | 27 | 18 | 2 |
| London Scottish | 1 | 1 | 0 | 0 | 36 | 26 | 10 | 2 |
| Bread & Roses | 1 | 1 | 0 | 0 | 35 | 26 | 9 | 2 |
| Aldersgate | 1 | 1 | 0 | 0 | 40 | 39 | 1 | 2 |
| Uncosy | 1 | 0 | 0 | 1 | 39 | 40 | -1 | 0 |
| Telstars | 1 | 0 | 0 | 1 | 26 | 35 | -9 | 0 |
| Rosslyn Park | 1 | 0 | 0 | 1 | 26 | 36 | -10 | 0 |
| Accrington Cylindricals | 1 | 0 | 0 | 1 | 27 | 45 | -18 | 0 |
| Ovalytes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Accrington Cylindricals James Collenette 14 | 27 - 45 | Waterloo Sunset Bob Jones 18 Charly Fitzpatrick 14 |
| Aldersgate Paul Spencer-Thompson 14 Tom Dineen 11 | 40 - 39 | Uncosy Peter Ediss 18 Will Jones 11 |
| London Scottish David Plastow 14 Alastair McLaggan 10 | 36 - 26 | Rosslyn Park |
| Telstars Bill Stratton 13 | 26 - 35 | Bread & Roses John McDonnell 17 |
| Pos | Division 1 | Pts | Avg | W | D | L |
| 1 | Broken Hearts | 41 | 51.00 | 8 | 0 | 2 |
| 2 | Nomads | 36 | 53.44 | 7 | 1 | 1 |
| 3 | Allsorts | 33 | 51.90 | 7 | 0 | 3 |
| 4 | Atletico | 28 | 48.67 | 5 | 0 | 4 |
| 5 | Old Itonians | 25 | 46.80 | 5 | 1 | 4 |
| 6 | Waterloo Sunset | 16 | 43.20 | 3 | 0 | 7 |
| 7 | Pineapple | 16 | 42.20 | 3 | 0 | 7 |
| 8 | Barb | 15 | 41.50 | 3 | 0 | 7 |
| 9 | Gray Monks | 8 | 39.30 | 2 | 0 | 8 |
| Pos | Division 2 | Pts | Avg | W | D | L |
| 1 | Pericardium | 41 | 53.80 | 9 | 0 | 1 |
| 2 | Belly | 34 | 43.67 | 8 | 0 | 1 |
| 3 | Ovalytes | 29 | 40.70 | 7 | 0 | 3 |
| 4 | Rosslyn Park | 28 | 41.30 | 6 | 0 | 4 |
| 5 | Telstars | 21 | 40.40 | 4 | 1 | 5 |
| 6 | Mealy Bugs | 18 | 37.90 | 4 | 1 | 5 |
| 7 | Accrington Cylindricals | 15 | 36.60 | 3 | 0 | 7 |
| 8 | Wharfside | 9 | 26.60 | 2 | 0 | 8 |
| 9 | London Scottish | 3 | 31.67 | 0 | 0 | 9 |